2022
- Hunting out the autophagic problem in Huntington disease. Pircs K, Barker RA, Jakobsson J.
Download publication - Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes. Hezemans FH, Wolpe N, O’Callaghan C, Ye R, Rua C, Jones PS, Murley AG, Holland N et al.
Download publication - Locus coeruleus integrity from 7 T MRI relates to apathy and cognition in Parkinsonian disorders. Ye R, O’Callaghan C, Rua C, Hezemans FH, Holland N et al.
Download publication - Combining biomarkers for prognostic modelling of Parkinson’s disease. Vijiaratnam N, Lawton M, Helsgrave AJ, Guo T, Tan M, Jabbari E et al.
Download publication - Level I PD-MCI using global cognitive tests and the risk for Parkinson’s disease dementia. Boel JA, deBie RMA, Schmand BA, Dalrymple-Alford JC et al.
Download publication - Metacognitive insight into cognitive performance in Huntington’s disease gene carriers. Hewitt SR, White AJ, Mason SL, Barker RA.
Download publication - GBA and APOE impact cognitive decline in Parkinson’s Disease: A 10-year population-based study. Szwedo A, Dalen I, Pedersen K, Camacho M et al.
Download publication - Long-term effectiveness of adjuvant treatment with carechol-o-methyltransferase or monamine oxidase B inhibitors compared with dopamine agonists amoung patients with Parkinson Disease uncontrolled by Levodopa therapy: The PD MED randomized clinical trial. Gray R, Patel S, Ives N, Rick C, Woolley R et al.
Download publication - The utility of breath analysis in the diagnosis and staging of Parkinson’s Disease. Stott S, Y Broza Y, Gharra A, Wang Z, Barker R, Haick H.
- Exploring the predictors of financial impairment in Huntington’s disease using the Enroll-HD dataset. Harris K, Mason S, Barker R.
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2021
- Reprogramming Human Adult Fibroblasts into GABAergic Interneurons. Bruzelius A, Kidnapillai S, Drouin-Ouellet J, Stoker T, Barker RA, Rylander Ottosson D.
Download publication - Distinct subcellular autophagy impairements in induced neurons from Huntington’s disease patients. Pircs K, Drouin-Ouellet J, Horvath V, Gil J, Rezeli M, Garza R et al.
Download publication - GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain. Dar GH, Mendes CC, Kuan WL, Speciale AA et al.
Download publication - In vivo 18F-flortaucipir PET does not accurately support the staging of progressive supranuclear palsy. Malpetti M, Kaalund SS, Tsvetanova KA, Rittman T, Briggs M, Allinson K, Passamonti L, Holland N, Jones PS, Fryer TD, Hong YT et al.
Download publication - Biofunctional bacterial cellulose scaffold supports the patterning and expansion of human embryonic stem cell-derived dopaminergic progenitor cells. Robbins M, Pisupati V, Azzarelli R, Nehme SI, Barker RA, Fruk L, Schierle GSK.
Download publication - The origins of the Protein Spread in Parkinson’s Disease. Barker RA.
Download publication - Reduced expression of dopamine D2 receptors on astrocytes in R6/1 HD mice and HD post-mortem tissue.Harris KL, Mason SL, Vallin B, Barker RA.
Download publication - T lymphocyte senescence is attenuated in Parkinson’s disease. Kouli A, Jensen M, Papastavrou V, Scott KM, Kolenda C, Parker C, Solim IH, Camacho M, Martin-Ruiz C, Williams-Gray CH.
Download publication - The immunogenicity of midbrain dopaminergic neurons and the implications for neural grafting trials in Parkinson’s disease.Qarin S, Howlett SK, Jones JL, Barker RA.
Download publication - Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases. Cai N, Gomez-Duran A, Yonova-Doing E, Kundu K, Burgess AI, Golder ZJ, Calabrese C, Bonder MJ et al.
Download publication - Cells of the human intestinal tract mapped across space and time. Elmentaite R, Kumasaka N, Roberts K, Fleming A, Dann E, King HW, Kleshchevnikov V et al.
Download publication - A roadmap for the Human Developmental Cell Atlas. Haniffa M, Taylor D, Linnarsson S, Aronow BJ, Bader GD, Barker RA, Camara PG, Camp JG et al.
Download publication - The cerebrospinal fluid profile of cholesterol metabolites in Parkinson’s Disease and their assoiciation with disease state and clinical features.Griffiths WJ, Abdel-Khalik J, Moore SF, Wijeyekoon RS, Crick PJ, Yutuc E, Farrell K, Breen DP, Williams-Gray CH, Theofilopoulos S, Arenas E, Trupp M, Barker RA, Wang Y.
Download publication - [18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in lewy body diseases. Mak E, Kouli A, Holland N, Nicastro N, Savulich G, Surendranathan A et al.
Download publication - Huntington’s disease: diagnosis and management. Stoker TB, Mason SL, Greenland JC, Holden ST, Santini H, Barker RA.
Download publication - Stem Cell-Derived Dopamine Neurons: Will they replace DBS as the leading neurosurgical treatment for Parkinson’s Disease?
Download publication - ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update. Lovell-Badge R, Anthony E, Barker RA, Bubela T et al.
Download publication - Problems with Social Cognition and Decision-Making in Huntington’s Disease: Why Is it Important? Mason SL, Schaepers M and Barker RA.
Download publication - Single cell derived mRNA signals across human kidney tumors. Young MD, Mitchell TJ, Custers L et al.
Download publication - Late-onset Huntington’s disease associated with CAG repeat lengths of 30 and 31. Stoker TB, Holden ST, Barker RA.
Download publication - The Gastrointestinal Dysfunction Scale for Parkinson’s Disease. Camacho M, Greenland JC and Williams-Gray CH.
Download publication - Early constipation predicts faster dementia onset in Parkinson’s disease. Camacho M, Macleod AD, Maple-Grodem J, Evans JR, Breen DP, Cummins G, Wijeyekoon RS, Greenland JC, Alves G, Tysnes OB, Lawson RA, Barker RA and Williams-Gray CH.
Download publication - Bringing Advanced Therapy Medicinal Products (ATMPs) for Parkinson’s Disease to the Clinic: The Investigator’s Perspective. Barker RA, Cutting EV and Daft DM.
Download publication - MEIS-WNT5A axis regulates developments of fourth ventricle choroid plexus. Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, Bukova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, Bryja V.
Download publication - Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson’s Disease in the ICICLE-PD Cohort. Lawson RA, Williams-Gray CH, Camacho M, Duncan GW, Khoo TK, Breen DP, Barker RA, Rochester L, Burn DJ, Yarnall AJ; ICICLE-PD study group.
Download publication - Longitudinal changes in movement-related functional MRI activity in Parkinson’s disease patients. Hannaway N, Lao-Kaim NP, Martín-Bastida A, Roussakis AA, Howard J, Wall MB, Loane C, Barker RA, Piccini P.
Download publication - Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson’s disease. Liu G, Peng J, Liao Z, Locascio JJ, Corvol JC, Zhu F, Dong X, Maple-Grødem J, Campbell MC, Elbaz A, Lesage S, Brice A, Mangone G, Growdon JH, Hung AY, Schwarzschild MA, Hayes MT, Wills AM, Herrington TM, Ravina B, Shoulson I, Taba P, Kõks S, Beach TG, Cormier-Dequaire F, Alves G, Tysnes OB, Perlmutter JS, Heutink P, Amr SS, van Hilten JJ, Kasten M, Mollenhauer B, Trenkwalder C, Klein C, Barker RA, Williams-Gray CH, Marinus J; International Genetics of Parkinson Disease Progression (IGPP) Consortium, Scherzer CR.
Download publication - The coding and long noncoding single-cell atlas of the developing human fetal striatum. Bocchi VD, Conforti P, Vezzoli E, Besusso D, Cappadona C, Lischetti T, Galimberti M, Ranzani V, Bonnal RJP, De Simone M, Rossetti G, He X, Kamimoto K, Espuny-Camacho I, Faedo A, Gervasoni F, Vuono R, Morris SA, Chen J, Felsenfeld D, Pavesi G, Barker RA, Pagani M, Cattaneo E.
Download publication - A Quantitative model of cellular decision making in direct neuronal reprogramming. Merlevede A, Legault EM, Drugge V, Barker RA, Drouin-Ouellet J, Olariu V.
Download publication - Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell. Kildisiute G, Kholosy WM, Young MD, Roberts K, Elmentaite R, van Hooff SR, Pacyna CN, Khabirova E, Piapi A, Thevanesan C, Bugallo-Blanco E, Burke C, Mamanova L, Keller KM, Langenberg-Ververgaert KPS, Lijnzaad P, Margaritis T, Holstege FCP, Tas ML, Wijnen MHWA, van Noesel MM, Del Valle I, Barone G, van der Linden R, Duncan C, Anderson J, Achermann JC, Haniffa M, Teichmann SA, Rampling D, Sebire NJ, He X, de Krijger RR, Barker RA, Meyer KB, Bayraktar O, Straathof K, Molenaar JJ, Behjati S.
Download publication - Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease. O’Callaghan C, Hezemans FH, Ye R, Rua C, Jones PS, Murley AG, Holland N, Regenthal R, Tsvetanov KA, Wolpe N, Barker RA, Williams-Gray CH, Robbins TW, Passamonti L, Rowe JB.
Download publication - Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson’s Disease. Tan MMX, Lawton MA, Jabbari E, Reynolds RH, Iwaki H, Blauwendraat C, et al.
Download publication - Parkinson’s disease laterality: a (11)C-PE2I PET imaging study. Roussakis AA, Zeng Z, Lao-Kaim NP, Martin-Bastida A et al.
Download publication - Comparison of Patient and Expert Perceptions of the Attainment of Research Milestones in Parkinson’s Disease. Kane PB, Benjamin DM, Barker RA, Lang AE, Sherer T, Kimmelman J.
Download publication - Differences in the Presentation and Progression of Parkinson’s Disease by Sex. Iwaki H, Blauwendraat C, Leonard HL, Makarious MB, Kim JJ, Liu G, et al.
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2020
- The sleep and circadian problems of Huntington’s disease: when, why and their importance. Voysey Z, Fazal SV and Barker RA. 2020 December
Download publication - Neuroinflammation and Protein Pathology in Parkinson’s Disease Dementia. Kouli A, Camacho M, Allinson K and Williams-Gray CH. 2020 December
Download publication - A Blueprint For Translational Regenerative Medicine. Armstrong JPK, Keane TJ, Roques AC, Stephen Patrick P, Mooney CM, Kuan WL, Pisupati V, Oreffo ROC, Stuckey DJ, Watt FM, Forbes SJ, Barker RA and Stevens MM. 2020 December
Download publication - The Treatment of Sleep Dysfunction in Neurodegenerative Disorders. Voysey ZJ, Barker RA, Lazar AS. 2020 November
Download publication - Azathioprine immunosuppression and disease modification in Parkinson’s disease (AZA-PD): a randomised double-blind placebo-controlled phase II trial protocol. Greenland JC, Cutting E, Kadyan S, Bond S, Chhabra A, Williams-Gray CH. 2020 November
Download publication - Hydrocephalus Complicating Intrathecal Antisense Oligonucleotide Therapy for Huntington’s Disease. Stoker TB, Andresen KER, Barker RA. 2020 October
Download publication - Gene and Cell-based Therapies for Parkinson’s Disease: Where Are We? Buttery PC, Barker RA. 2020 October
Download publication - The Clinical Features and Progression of Late-Onset Versus Younger-Onset in an Adult Cohort of Huntington’s Disease Patients. Anil M, Mason SL, Barker RA. October 2020
Download publication - Huntingtin-lowering strategies for Huntington’s Disease. Barker RA, Fujimaki M, Rogers P, Rubinsztein DC. 2020 October
Download publication - GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop. Barker RA, Björklund A, Gash DM, Whone A, Van Laar A, Kordower JH, Bankiewicz K, Kieburtz K, Saarma M, Booms S. July 2020
Download publication - Timing is Everything: The T‐Cell Response to α‐Synuclein Is Maximal in Early Parkinson’s. Kouli A, Williams-Gray CH. 2020 July
Download publication - Animal Models of Parkinson’s Disease: Are They Useful or Not? Barker RA, Bjorklund A. 2020 July
Download publication - Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson’s disease. Ramsay N, Macleod AD, Alves G, Camacho M, Forsgren L, Lawson RA, Maple-Grodem J, Tysnes O, Williams-Gray CH, Yarnall AJ, Counsell CE et al., 2020 July
Download publication - Cerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson’s Disease. Wijeyekoon RS, Moore SF, Farrell K, Breen DP, Barker RA, Williams-Gray CH. June 2020
Download publication - GDNF and Parkinson’s Disease – Where Next? Barker RA, Bjorklund A, Gash DM, Whone A, Van Laar A et al. 2020 June
Download publication - A common polymorphism in SNCA is associated with accelerated motor decline in GBA-Parkinson’s disease.
- Antidopaminergic treatment is associated with reduced chorea and irritability but impaired cognition in Huntington’s disease (Enroll-HD). Harris KL, Kuan WL, Mason SL, Barker RA. June 2020
Download publication - Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques. Mousavinejad M, Skidmore S, Barone FG, Tyers P, Pisupati V, Poptani H, Plagge A, Barker RA, Murray P, Taylor A, Hill CJ. 2020 May.
Download Publication - Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management. O’Brien J, Taylor JP, Ballard C, Barker RA, Bradley C, Burns A, Collerton D, Dave S, Dudley R, Francis P, Gibbons A, Harris K et al., 2020 May
Download publication - Implantation of the clinical-grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington’s disease. Yoon Y, Kim HS, Jeon I, Noh JE, Park HJ, Lee S, Park IH, Stevanato L, Hicks C, Corteling R, Barker RA, Sinden JD, Song J. 2020 May
Download Publication - A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity. Koch K, Hartmann R, Tsiampali J, Uhlmann C, Nickel AC, He X, Kamp MA, Sabel M, Barker RA et al. 2020 April
Download Publication - Forecasts for the Attainment of Major Research Milestones in Parkinson’s Disease. Kane PB, Benjamin DM, Barker RA, Lang AE, Sherer T, Kimmelman J. 2020 April
Download Publication - The Dementias Platform UK (DPUK) Data Portal. Bauermeister S, Orton C, Thompson S, Barker RA, Bauermeister JR, Ben-Shlomo Y et al. 2020 April
Download Publication - Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson’s disease. Stoker TB, Camacho M, Winder-Rhodes S, Liu G, Scherzer CR, Foltynie T, Evans J, Breen DP, Barker RA, Williams-Gray CH. 2020 April
Download Publication - Disease modification and biomarker development in Parkinson disease: Revision or reconstruction? Espay AJ, Kalia LV, Gan-Or Z, Williams-Gray CH, Bedard PL, Rowe SM et al. 2020 March.
Download Publication - Informed consent for stem cell-based interventions-reply. Charo RA, Barker RA, Sugarman J. 2020 March.
Download Publication - Serum raman spectroscopy as a diagnostic tool in patients with Huntington’s disease. Huefner A, Kuan WL, Mason SL, Mahajan S, Barker RA. 2020 Jan.
Download Publication - Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management. O’Brien J, Taylor JP, Ballard C, Barker RA, Bradley C et al. 2020 March.
Download Publication - A cell atlas of human thymic development defines T Cell repertoire formation. Park JE, Botting RA, Dominguez Conde C et al. 2020 Feb.
Download Publication - Parkinson’s disease and spirituality. Redfern C, Mason SL, Barker RA, Coles A. 2020 Feb.
Download Publication - Progression of neuropsychiatric symptoms over time in an incident Parkinson’s disease cohort (ICICLE-PD). Dlay JK, Duncan GW, Khoo TK, Williams-Gray CH, Breen DP, Barker RA, Burn DJ, Lawson RA, Yarnall AJ. 2020 Feb.
Download Publication - Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson’s disease. Wijeyekoon RS, Kronenberg-Versteeg D, Scott KM, Hayat S, Kuan WL, Evans JR, Breen DP, Cummins G, Jones JL, Clatworthy MR, Floto RA, Barker RA, Williams -Gray CH. 2020 Jan.
Download Publication - Motor complications in Parkinson’s disease: 13-year follow up of the CamPaIGN cohort. Kim HJ, Mason S, Foltynie T, Winder-Rhodes S, Barker RA, Williams-Gray CH. 2020 Jan Download Publication
- Senescence and Inflammatory markers for predicting clinical progression in Parkinson’s disease: The ICICLE-PD Study. Martin-Ruiz C, Williams-Gray CH, Yarnall AJ, Boucher JJ, Lawson RA, Wijeyekoon RS, Barker RA, Kolenda C, Parker C, Burn DJ, Von Zglinicki T, Saretzki G. 2020
Download Publication - DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits. Solti K, Kuan WL, Forizs B, Kustos G, Mihaly J, Varga Z, Herberth B, Moravcsik E, Kiss R, Karpati M, Mikes A, Zhao Y, Imre T, Rochet JC, Aigbirhio F, Williams-Gray CH, Barker RA, Toth G. 2020 Feb
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2019
- Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson’s disease. Kuan WL, Stott K, He x, Wood TC, Yang S, Kwok JCF, Hall K, Zhao Y, Tietz O, Aigbirhio FI, Vernon AC, Barker RA. 2019 Nov
Download Publication - Association between toll-like receptor 4 (TLR4) and triggering receptor expressed on Myeloid cells 2 (TREM2) genetic variants and clinical progression of Huntington’s disease. Vuono R, Kouli A, Legault EM, Chagnon L, Allinson KS, La Spada A; REGISTRY investigators of the european Huntington’s disease network, Biunno I, Barker RA, Drouin-Ouellet J. 2019 Nov
Download Publication - Dual modulation of neuro-specific microRNAs and the REST complex promotes functional maturation of human adult induced neurons. Birtele M, Sharma Y, Kidnapillai S, Lau S, Stoker TB, Barker RA, Rylander Ottosson D, Drouin-Ouellet J, Parmar M. 2019 Dec
Download Publication - Loss of FBXO7 results in a Parkinson’s-like dopaminergic degeneration via an RPL23-MDM2-TP53 pathway. Stott SRW, Randle SJ, AL Rawi S, Rowicka P, Harris R, Mason B, Xia J, Dalley JW, Barker RA, Laman H. 2019 Oct
Download Publication - Toll-like receptors and their therapeutic potential in Parkinson’s disease and a-synucleinopathies. Kouli A, Horne CB, Williams-Gray CH. 2019 Oct
Download Publication - Genomewide association study of Parkinson’s disease clinical biomarkers in 12 longitudinal patients’ cohorts. Iwaki H, Blauwendraat C, Leonard HL, Kim JJ, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Hutten SJ, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, Wijeyekoon R, Van Deerlin VM, Hernandez DG, Gibbs JR; International Parkinson’s Disease Genomics Consortium, Chitrala KN, Day-Williams AG, Brice A, Alves G, Noyce AJ, Tysnes OB, Evans JR, Breen DP, Estrada K, Wegel CE, Danjou F, Simon DK, Andreassen O, Ravina B, Toft M, Heutink P, Bloem BR, Weintraub D, Barker RA, Williams-Gray CH, van de Warrenburg BP, Van Hilten JJ, Scherzer CR, Singleton AB, Nalls MA. 2019 Dec
Download Publication - Huntington’s disease patients display progressive deficits in hippocampal-dependent cognition during a task of spatial memory. Harris KL, Armstrong M, Swain R, Erzinclioglu S, Das T, Burgess N, Barker RA, Mason SL. 2019 Oct
Download Publication - A touchscreen motivation assessment evaluated in Huntington’s Disease patients and R6/1 model mice. Heath CJ, O’Callaghan C, Mason SL, Phillips BU, Saksida LM, Robbins TW, Barker RA, Bussey TJ, Sahakian BJ. 2019 Aug
Download Publication - Pro-Saccades predict cognitive decline in Parkinson’s Disease: ICICLE-PD. Stuart S, Lawson RA, Yarnall AJ, Nell J, Alcock L, Duncan GW, Khoo TK, Barker RA, Rochester L, Burn DJ; ICICLE-PD study group. 2019 Nov
Download Publication - Genetic risk of Parkinson disease and progression: An analysis of 13 longitudinal cohorts. Iwaki H, Blauwendraat C, Leonard HL, Liu G, Maple-Grødem J, Corvol JC, Pihlstrøm L, van Nimwegen M, Hutten SJ, Nguyen KH, Rick J, Eberly S, Faghri F, Auinger P, Scott KM, Wijeyekoon R, Van Deerlin VM, Hernandez DG, Day-Williams AG, Brice A, Alves G, Noyce AJ, Tysnes OB, Evans JR, Breen DP, Estrada K, Wegel CE, Danjou F, Simon DK, Ravina B, Toft M, Heutink P, Bloem BR, Weintraub D, Barker RA, Williams-Gray CH, van de Warrenburg BP, Van Hilten JJ, Scherzer CR, Singleton AB, Nalls MA. 2019 Jul
Download Publication - A professional standard for informed consent from stem cell therapies. Sugarman J, Barker RA, Charo RA.
Download Publication - Genetic analysis of Mendelian mutations in a large UK population-based Parkinson’s disease study. Tan MMX, Malek N, Lawton MA, Hubbard L, Pittman AM, Joseph T, Hehir J, Swallow DMA, Grosset KA, Marrinan SL, Bajaj N, Barker RA, Burn DJ, Bresner C, Foltynie T, Hardy J, Wood N, Ben-Shlomo Y, Grosset DG, Williams NM, Morris HR. 2019 Sept
Download Publication - Designing stem-cell-based dopamine cell replacement trials for Parkinson’s disease. Barker RA, TRANSEURO consortium. 2019 Jul
Download Publication - Meaningful and measurable health domains in Huntington’s disease: Large-scale validation of the Huntington’s disease health-related quality of life questionnaire across severity stages. Ho AK, Horton MC, Landwehrmeyer GB, Burgunder JM, Tennant A, European Huntington’s Disease Network. 2019 Jun
Download Publication - Parkinson disease and growth factors – is GDNF good enough? Kirkeby A, Barker RA. 2019 Jun
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Download Publication - Using global team science to identify genetic Parkinson’s disease worldwide. Vollstedt EJ, Kasten M, Klein C; MJFF Global Genetic Parkinson’s Disease study group. 2019 Jun 2
Download Publication - Platelet abnormalities in Huntington’s disease. Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Rowley JW, Cloutier N, Tremblay MÈ, Vincent AT, Gould PV, Chouinard S, Weyrich AS, Rondina MT, Barker RA, Boilard E, Cicchetti F. 2019 Mar
Download Publication - Portrait of blood-derived extracellular vesicles in patients in Parkinson’s disease. Lamontagne-Proulx J, St-Amour I, Labib R, Pilon J, Denis HL, Cloutier N, Roux-Dalvai F, Vincent AT, Mason SL, Williams-Gray C, Duchez AC, Droit A, Lacroix S, Dupré N, Langlois M, Chouinard S, Panisset M, Barker RA, Boilard E, Cicchetti F. 2019 Apr
Download Publication - Hyperosmotic stress induces cell-dependent aggregation of α-synuclein. Fragniere AMC, Stott SRW, Fazal SV, Andreasen M, Scott K, Barker RA. 2019 Feb.
Download Publication - L-Dopa responsiveness in early Parkinson’s disease is associated with the rate of motor progression. Malek N, Kanavou S, Lawton MA, Pitz V, Grosset KA, Bajaj N, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Hardy J, Williams NM, Wood N, Morris HR, Grosset DG; PRoBaND clinical consortium. 2019 May
Download Publication - Targeting Huntingtin Expression in Patients with Huntington’s Disease. Tabrizi SJ, Leavitt BR, Landwehrmeyer GB, Wild EJ, Saft C, Barker RA, Blair NF, Craufurd D, Priller J, Rickards H, Rosser A, Kordasiewicz HB, Czech C, Swayze EE, Norris DA, Baumann T, Gerlach I, Schobel SA, Paz E, Smith AV, Bennett CF, Lane RM. 2019 May.
Download Publication - Relationship between neuromelanin and dopamine terminals within the Parkinson’s nigrostriatal system. Martin-Bastida A, Lao-Kaim NP, Roussakis AA, Searle GE, Xing Y, Gunn RN, Schwarz ST, Barker RA, Auer DP, Piccini P. 2019 May.
Download Publication - WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis. Kaiser K, Gyllborg D, Prochazka J, Salasova A, Kompanikova P, Molina FL, Laguna-Goya R, Radaszkiewicz T, Harnos J, Prochazkova M, Potesil D, Barker RA, Casado AG, Zdrahal Z, Sedlacek R, Arenas E, Villaescusa JC, Bryja V. 2019 Apr
Download Publication - Assessment of the Performance of a Modified Motor Scale as Applied to Juvenile Onset Huntington’s Disease. Horton MC, Nopoulos P, Nance M, Landwehrmyer GB, Barker RA, Squitieri F; REGISTRY Investigators of the European Huntington’s Disease Network, Burgunder JM, Quarrell O. 2019
Download Publication - Inflammation in mild cognitive impairment due to Parkinson’s disease, Lewy body disease, and Alzheimer’s disease. King E, O’Brien J, Donaghy P, Williams-Gary CH, Lawson RA, Morris CM, Barnettt N, Olsen K, Martin-Ruiz C, Burn D, Yarnall AJ, Taylor JP, Duncan G, Khoo TK, Thomas A. 2019 Apr 16.
Download Publication - Clinical and genetic characteristics of late-onset Huntington’s disease. Oosterloo M, Bijlsma EK, van Kuijk SM, Minkels F, de Die-Smulders CE; REGISTRY Investigators of the European Huntington’s Disease Network; Registry Steering committee; Language coordinators; EHDN’s associate site in Singapore. 2019 Apr.
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2018
- Tackling ethical challenges of premature delivery of stem cell-based therapies: ISSCR 2018 annual meeting focus session report. Sugarman J, Barker RA, Kerridge I, Lysaght T, Pellegrini G, Sipp D, Tanner C. 2018 Nov.
Download Publication - The peripheral inflammatory response to alpha-synuclein and endotoxin in Parkinson’s Disease. White AJ, Wijeyekoon RS, Scott KM, Gunawardana NP, Hayat S, Solim IH, McMahon HT, Barker RA, Williams-Gray CH. 2018 Nov.
Download Publication - Monocyte function in Parkinson’s disease and the impact of autologous serum on phagocytosis. Wijeyekoon RS, Kronenberg-Versteeg D, Scott KM, Hayat S, Jones JL, Clatworthy MR, Floto RA, Barker RA, Williams-Gray CH. 2018 Oct.
Download Publication - A systematic review and meta-analysis of alpha synuclein auto-antibodies in Parkinson’s Disease. Scott KM, Kouli A, Yeoh SL, Clatworthy MR, Williams-Gray CH. 2018
Download Publication - Emerging treatment approaches for Parkinson’s disease. Stoker TB, Toesney KM, Barker RA. 2018 Oct
Download Publication - Outcome of cell suspension allografts in a patient with Huntington’s disease. Maxan A, Mason S, Saint-Pierre M, Smith E, Ho A, Harrower T, Watts C, Tai Y, Pavese N, Savage JC, Tremblay MÈ, Gould P, Rosser AE, Dunnett SB, Piccini P, Barker RA, Cicchetti F. 2018 Oct.
Download Publication - Multimorbidity predicts quality of life but not motor severity in early Parkinson’s disease. Gravell R, Duncan GW, Khoo TK, Burn DJ, Sayer AA, Barker RA, Lawson RA, Yarnall AJ. 2018 Aug.
Download Publication - Long-term follow-up of a phase I/II study of prosavin, a lentiviral vector gene therapy for Parkinson’s disease. Palfi S, Gurruchaga JM, Lepetit H, Howard K, Ralph GS, Mason S, Gouello G, Domenech P, Buttery PC, Hantraye P, Tuckwell NJ, Barker RA, Mitrophanous KA. 2018 Sept.
Download Publication - Huntingtin aggregation impairs autophagy, leading to argonaute-2 accumulation and global microRNA dysregulation. Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Lundh SH, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA, Jakobsson J. 2018 Aug.
Download Publication - The clinical heterogeneity of Parkinson’s disease and its therapeutic implications. Greenland JC, Williams-Gray CH, Barker RA. 2018 Jul.
Download Publication - Categorising visual hallucinations in early Parkinson’s disease. Clegg BJ, Duncan GW, Khoo TK, Barker RA, Burn DJ, Yarnall AJ, Lawson RA. 2018 Aug.
Download Publication - Regenerative therapies for Parkinson’s disease: An update. Stoker TB, Barker RA. 2018 Aug.
Download Publication - The motor and cognitive features of Parkinson’s disease in patients with concurrent Gaucher disease over 2 years: a case series. Collins LM, Williams-Gray CH, Morris E, Deegan P, Cox TM, Barker RA. 2018 Aug
Download Publication - Defective sphingosine-1-phosphate metabolism is a druggable target in Huntington’s disease. Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D’Esposito M, Bowman AB, Barker RA, Maglione V. 2018 May
Download Publication - Targeting aged astrocytes may be a new therapeutic strategy in Parkinson’s Disease. Scott KM, Williams-Gray CH. 2018 May
Download Publication - New approaches for brain repair-from rescue to reprogramming. Barker RA, Götz M, Parmar M. 2018 May
Download Publication - The challenges of first-in-human stem cell clinical trials: What does this mean for ethics and institutional review boards? Barker RA, Carpenter MK, Forbes S, Goldman SA, Jamieson C, Murry CE, Takahashi J, Weir G. 2018 May
Download Publication - Longitudinal diffusion tensor imaging changes in early Parkinson’s disease: ICICLE-PD study. Minett T, Su L, Mak E, Williams G, Firbank M, Lawson RA, Yarnall AJ, Duncan GW, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker RA, Burn D, O’Brien JT. 2018 Apr 25
Download Publication - Dynamic and Cell-Specific DACH1 Expression in Human Neocortical and Striatal Development. Castiglioni V, Faedo A, Onorati M, Bocchi VD, Li Z, Iennaco R, Vuono R, Bulfamante GP, Muzio L, Martino G, Sestan N, Barker RA, Cattaneo E. 2018 Apr 24
- Predicting clinical diagnosis in Huntington’s disease: An imaging polymarker. Mason SL, Daws RE, Soreq E, Johnson EB, Scahill RI, Tabrizi SJ, Barker RA, Hampshire A. 2018 March
Download Publication - Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts.Shrigley S, Pircs K, Barker RA, Parmar M, Drouin-Ouellet J. 2018 Feb 5
Download Video - Features of GBA-associated Parkinson’s disease at presentation in the UK Tracking Parkinson’s study. Malek N, Weil RS, Bresner C, Lawton MA, Grosset KA, Tan M, Bajaj N, Barker RA, Burn DJ, Foltynie T, Hardy J, Wood NW, Ben-Shlomo Y, Williams NW, Grosset DG, Morris HR; PRoBaND clinical consortium. 2018 Jan
Download Publication - Using Medical Claims Analyses to Understand Interventions for Parkinson Patients. Bloem BR, Ypinga JHL, Willis A, Canning CG, Barker RA, Munneke M, De Vries NM. 2018
Download Publication - C-PE2I and F-Dopa PET for assessing progression rate in Parkinson’s: A longitudinal study. Li W, Lao-Kaim, Roussakis AA, Martín-Bastida A, Valle-Guzman N, Paul G, Loane C, Widner H, Politis M, Foltynie T, Barker RA, Piccini P. 2018 Jan
Download Publication - Abnormalities of age-related T Cell senescence in Parkinson’s Disease. Williams-Gray CH, Wijeyekoon RS, Scott KM, Hayat S, Barker RA, Jones JL. 2018 May Download Publication
- Dermal fibroblasts from patients with Parkinson’s disease have normal GCase activity and autophagy compared to patients with PD and GBA mutations. Collins LM, Drouin-Ouellet J, Kuan WL, Cox T, Barker RA.2018 Feb
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2017
- Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson’s Disease: Dawn of a New Era. Barker RA, Parmar M, Studer L, Takahashi J. Cell Stem Cell. 2017 Nov 2
Download Publication - An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease. Underwood BR, Green-Thompson ZW, Pugh PJ, Lazic SE, Mason SL, Griffin J, Jones PS, Rowe JB, Rubinsztein DC, Barker RA. J Neurol 2017 Dec
Download Publication - Associations between Lifestyle Factors and Parkinson’s Disease in an Urban Sri Lankan Clinic Study. Wijeyekoon R, Suriyakumara V, Gamage R, Fernando T, Jayasuriya A, Amarasinghe D, Gunasekara H, Sirisena D, Amaratunga D, Muthukuda C, Barker RA, Williams-Gray C, De Silva R. Int Arch Med 2017 Sep
Download Publication - Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned? Drouin-Ouellet J, Pircs K, Barker RA, Jakobsson J, Parmar M. Front Neurosci. 2017 Sep
Download Publication - Spatial structure normalises working memory performance in Parkinson’s disease. Fallon SJ, Bor D, Hampshire A, Barker RA, Owen AM. Cortex. 2017 Nov
Download Publication - Parkinson disease: Defining PD subtypes – a step toward personalized management? Williams-Gray CH, Barker RA. Nat Rev Neurol. 2017 Aug
Download Publication - Normal aging and Parkinson’s disease are associated with the functional decline of distinct frontal-striatal circuits. Gruszka A, Hampshire A, Barker RA, Owen AM. Cortex. 2017 Aug
Download Publication - Using a smartphone-based self management platform to support medication adherence and clinical consultation in Parkinson’s disease. Lakshminarayana R, Wang D, Burn D, Chaudhuri KR, Galtrey C, Guzman NV, Hellman B, Ben James, Pal S, Stamford J, Steiger M, Stott RW, Teo J, Barker RA, Wang E, Bloem BR, van der Eijk M, Rochester L, Williams A. NPJ Parkinsons Dis. 2017 Jan
Download Publication - REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and – independent pathways. Droin-Ouellet J, Lau S, Brattas PL, Rylander Ottosson D, Pircs K, Grassi DA, Collins LM, Vuono R, Andersson Sjoland A, Westergren-thorsson G, Graff C, Minthon L, Toresson H, Barker RA, Jakobsson J, Parmar M. EMBO Mol Med. 2017 Aug
Download Publication - Identification of genetic variants associated with Huntington’s disease progression: a genome-wide association study. Hensman Moss DJ, Pardinas AF, Langbehn D, Lo K, Leavitt BR, Roos R, Durr A, Mead S; TRACK-HD investigators: REGISTRY investigators, Holmans P, Jones L, Tabrizi SJ. Lancet Neurol. 2017 Sep
Download Publication - Prediction of cognition in Parkinson’s disease with a clinical-genetic score: a longitudinal analysis of nine cohorts. Liu G, Locascio JJ, Corvol JC, Boot B, Liao Z, Page K, Franco D, Burke K, Jansen IE, Trisini-Lipsanopoulos A, Winder-Rhodes S, Tanner CM, Lang AE, Eberly S, Elbaz A, Brice A, Mangone G, Ravina B, Shoulson I, Cormier-Dequaire F, Heutink P, van Hilten JJ, Barker RA, Williams-Gray CH, Marinus J, Scherzer CR; HBS; CamPaIGN; PICNICS; PROPARK, PSG; PSG; DIGPD; PDBP. Lancet Neurol. 2017 Aug
Download Publication - Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD). Kirkeby A, Parmar M, Barker RA. Prog Brain Res. 2017
Download Publication - Cortical and Striatal Reward Processing in Parkinson’s Disease Psychosis. Garofalo S, Justicia A, Arrondo G, Ermakova AO, Ramachandra P, Tudor-Sfetea C, Robbins TW, Barker RA, Fletcher PC, Murray GK. Front Neurol. 2017 Apr
Download Publication - Neural grafting for Parkinson’s disease: challenges and prospects. Stoker TB, Blair NF, Barker RA. Neural Regen Res. 2017 Mar
Download Publication - Utility of the new Movement Disorder Society clinical diagnostic criteria for Parkinson’s disease applied retrospectively in a large cohort study of recent onset cases. Malek N, Lawton MA, Grosset KA, Bajaj N, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Hardy J, Morris HR, Williams NM, Wood N, Grosset DG; PRoBaND clinical consortium. Parkinsonism Relat Disord. 2017 Jul
Download Publication - Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson’s disease. Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, Duncan GW, Mollenhauer B, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker RA, Burn DJ, O’Brien JT. Neurobiol Aging. 2017 Aug
Download Publication - A non- cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS. Bao L. Al-Assar O, Drynan LF, Arends MJ, Tyers P, Barker RA, Rabbitts TH. Sci Rep. 2017 Mar Download Publication
- Cerebral glucose metabolism and cognition in newly diagnosed Parkinson’s disease: ICICLE-PD study. Firbank MJ, Yarnall AJ, Lawson RA, Duncan GW, Khoo TK, Petrides GS, O’Brien JT, Barker RA, Maxwell RJ, Brooks DJ, Burn DJ. J Neurol Neurosurg Psychiatry. 2017 Apr
Download Publication - Formation of hippocampal mHTT aggregates leads to impaired spatial memory, hippocampal activation and adult neurogenesis. Schwab LC, Richetin K, Barker RA, Deglon N. Neurobiol Dis. 2017 Jun
Download Publication - Stability of mild cognitive impairment in newly diagnosed Parkinson’s disease. Lawson RA, Yarnall AJ, Duncan GW, Breen DP, Khoo TK, Williams-Gray CH, Barker RA, Burn DJ; ICICLE-PD study group. J Neurol Neurosurg Psychiatry. 2017 Aug
Download Publication - CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson’s disease. Stott SR, Hayat S, Carnwath T, Garas S, Sleeman JP, Barker RA. PLoS One. 2017 Feb Download Publication
- Anxiety is associated with cognitive impairment in newly-diagnosed Parkinson’s disease. Dissanayaka NN, Lawson RA, Yarnall AJ, Duncan GW, Breen DP, Khoo TK, Barker RA, Burn DJ; ICICLE-PD study group. Parkinsonism Relat Disord. 2017 March
Download Publication - Intra-and inter-network functional alterations in Parkinson’s disease with mild cognitive impairment. Peraza LR, Nesbitt D, Lawson RA, Duncan GW, Yarnall AJ, Khoo TK, Kaiser M, Firbank MJ, O’Brien JT, Barker RA, Brooks DJ, Burn DJ, Taylor JP. Hum Brain Mapp. 2017 Mar
Download Publication - Motor associations of iron accumulation in deep grey matter nuclei in Parkinson’s disease: a cross-sectional study of iron-related magnetic resonance imaging susceptibility. Martin-Bastida A, Lao-Kaim NP, Loane C, Politis M, Roussakis AA, Valle-Guzman N, Kefalopoulou Z, Paul-Visse G, Widner H, Xing Y, Schwarz ST, Auer DP, Foltynie T, Barker RA, Piccini P. Eu J Neurol. 2017 Feb
Download Publication - Neuroendocrine abnormalities in Parkinson’s disease. De Pablo-Fernandez E, Breen DP, Bouloux PM, Barker RA, Foltynie T, Warner TT. J Neurol Neurosurg Psychiatry. 2017 Feb
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2016
- Neuropathic Gaucher’s mutations accelerate cofnitive decline in Parkinson’s. Liu G, Boot B, Locascio JJ, Jansen IE, Winder-Rhodes S, Eberly S, Elbaz A, Brice A, Ravina B, Van Hilten JJ, Cormier-Dequaire F, Corvol JC, Barker RA, Heutink P, Marinus J, Williams-Gray CH, Scherzer CR; for the International Genetics of Parkinson Disease Progression (IGPP) Consortium. 2016 Sept 22
Download Publication - Cognitive decline and quality of life in incident Parkinson’s disease: The role of attention. Lawson RA, Yarnall AJ, Duncan GW, Breen DP, Khoo TK, Williams-Gray CH, Barker RA, Collerton D, Taylor JP, Burn DJ, ICICLE-PD study group. Parkinsonism Relat Disorder. 2016 Jun
Download Publication - Time on timing: Dissociating premature responding from interval sensitivity in Parkinson’s disease. Zhang J, Nombela C, Wolpe N, Barker RA, Rowe JB. Movement Disorder. 2016 Apr 19
Download Publication - Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson’s disease with clinical and neuroimaging measures. Ye Z, Rae CL, Nombela C, Ham T, Rittman T, Jones PS, Rodriguez PV, Coyle-Gilchrist I, Regenthal R et al. Human Brain Mapp. 2016 Mar
Download Publication - Comparative epidemiology of incident Parkinson’s disease in Cambridgeshire, UK. Evans JR, Cummins G, Breen DP, Foltynie T, Mason SL, Brayne CE, Williams-Gray CH, Barker RA. J Neurol Neurosurg Psychiatry. 2016 Jan 22
Download Publication - Hippocampal dysfunction defines disease onset in Huntington’s disease.Begeti F, Schwab LC, Mason SL, Barker RA. J Neurol Neurosurg Psychiatry. 2016 Feb 01
Download Publication - Development and external validation of a prognostic model in newly diagnosed disease. Velseboer DC, Die Bie RM, Wieske L, Evans JR, Mason SL, Foltynie T, Schmand B, De Haan RJ, Post B, Barker RA, Williams-Gray CH. Neurology. 2016 March 15
Download Publication - Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease. Breen DP, Nombela C, Vuono R, Jones PS, Fisher K, Burn DJ, Brooks DJ, Reddy AB, Rowe JB, Barker RA. Mov Disord. 2016 March 12
Download Publication - Deletions at 22q11.2 in idiopathic Parkinson’s disease: a combined analysis of genome-wide association data. Mok KY, Sheerin U, Simon-Sanchez J, Salaka A, Chester L et al. Lancet Neurol. 2016 March 23
Download Publication - Variation in recent onset Parkinson’s Disease: implications for prodromal detection. Swallow DM, Lawton MA, Grosset KA, Malek N, Smith CR, Bajaj NP, Barker RA et al. J Parkinsons Dis. 2016 March 19
Download Publication - Serum immune markers and disease progression in an incident Parkinson’s disease cohort (ICICLE-PD). Williams-Gray CH, Wijeyekoon R, Yarnall AJ, Lawson RA, Breen DP, Evans JR et al. Mov Disord. 2016 March 21
Download Publication - Advancing pharmacotherapy for treating Huntington’s disease: a review of the existing literature. Mason SL, Barker RA. Expert Opin Pharmacother. 2016 Jan
Download Publication - Different decision deficits impair response inhibition in progressive supranuclear palsy and Parkinson’s disease. Zhang J, Rittman T, Nombela C, Fois A, Coyle-Gilchrist I, Barker RA, Hughes LE, Rowe JB. Brain 2016 Jan
Download Publication - Are stem cell-based therapies for Parkinson’s Disease ready for clinic in 2016? Barker RA, Parmar M, Kirkeby A, Bjorklund A, Thompson L, Brundin P. Journal of Parkinson’s Disease 2016 March
Download Publication - A new biomarker for Parkinson’s disease? (commentary). Williams-Gray CH. Mov Disord. 2016 Jan
Download Publication - The spectrum of clinical features seen with alpha synuclein pathology. Barker RA, Williams-Gray CH. Neuropathol Appl Neurobiol. 2016 Jan
Download Publication2015
- Anticholinergic Load: Is there a Cognitive Cost in Early Parkinson’s Disease? Yarnall AJ, Lawson RA, Duncan GW, Breen DP, Khoo TK, Brooks D, Barker RA, Taylor JP, Burn DJ. J Parkinsons Dis. 2015 Oct 2
Download Publication - Tracking Parkinson’s: Study Design and Baseline Patient Data. Malek N, Swallow DM, Grosset KA, Lawton MA, Marrinan SL, Lehn AC, Bresner C, Bajaj N, Barker RA, Ben-Shlomo Y, Burn DJ, Foltynie T, Hardy J, Morris HR, Williams NM, Wood N, Grosset DG. J Parkinsons Dis. 2015 Oct 31
Download Publication - Olfaction in Parkin single and compound heterozygotes in a cohort of young onset Parkinson’s disease patients. Malek N, Swallow DM, Grosset KA, Lawton MA, Smith CR, Bajaj NP, Barker RA, Ben-Shlomo Y, Bresner C, Burn DJ, Foltynie T, Morris HR, Williams N, Wood NW, Grosset DG, PRoBaNd Investigators. Acta Neurol Scand. 2015 Dec
Download Publication - Characterization and Visualization of Vesicles in the Endo-Lysosomal Pathway with Surface-Enhanced Raman Spectroscopy and Chemometrics. Huefner A, Kuan WL, Müller KH, Skepper JN, Barker RA, Mahajan S. ACS Nano. 2015 Dec 18
Download Publication - A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain. Choi ML, Begeti F, Barker RA, Kim N. Hippocampus. 2015 Oct 7
Download Publication - Sleep, but no metabolic, deficits in pre-manifest huntington’s disease. Lazar AS, Panin F, Goodman AO, Lazic SE, Lazar ZI, Mason SL, Rogers L, Murgatroyd PR, Watson L, Singh P, Borowsky B, Shneerson JM, Barker RA. Ann Neurol. 2015 Jul 29.
Download Publication - Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson’s disease? Duncan GW, Firbank MJ, Yarnall AJ, Khoo TK, Brooks DJ, Barker RA, Burn DJ, O’Brien JT. Mov Disord. 2015
Download Publication - Baseline and longitudinal grey matter changes in newly diagnosed Parkinson’s disease: ICICLE-PD study. Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, Duncan GW, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker RA, Burn DJ, O’Brien JT. Brain. 2015 Jul
Download Publication - Dopamine and Huntington’s disease. Schwab LC, Garas SN, Drouin-Ouellet J, Mason SL, Stott SR, Barker RA. Expert Rev Neurother. 2015 Mar 16:1-14
Download Publication - Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease. Kim JI, Long JD, Mills JA, Downing N, Williams JK, Paulsen JS; the PREDICT-HD Investigators and Coordinators of the Huntington Study Group. Eur J Hum Genet. 2015 Mar 4. doi: 10.1038
Download Publication - Winder-Rhodes SE, Hampshire A, Rowe JB, Peele JE, Robbins TW, Owen AM, Barker RA. (2015). Association between MAPT haplotype and memory function in patients with Parkinson’s disease and healthy aging individuals. Neurobio Aging. 36: 1519-28.
Download Publication - Poole E, Kuan WL, Barker R, Sinclair J. (2015). The human cytomegalovirus non-coding Beta2.7 RNA as a novel therapeutic for Parkinson’s disease – Translational research with no translation.Virus Res. May 21. pii: S0168-1702(15)00178-1. [Epub ahead of print].
Download Publication - Cruickshank TM, Thompson JA, Dominguez D JF, Reyes AP, Bynevelt M, Georgiou-Karistianis N, Barker RA, Ziman MR. (2015). The effect of multidisciplinary rehabilitation on brain structure and cognition in Huntington’s disease: an exploratory study. Brain Behav. [Epub ahead of print].
Download Publication - Loftus AM, Bucks RS, Thomas M, Kane R, Timms C, Barker RA, Gasson N. (2015). Retrospective assessment of movement disorder society criteria for mild cognitive impairment in Parkinson’s disease. J Int Neuropsychol. 21:137-45.
Download Publication - Mason SL, Zhang J, Begeti F, Guzman NV, Lazar AS, Rowe JB, Barker RA, Hampshire A. (2015). The role of the amygdala during emotional processing in Huntington’s disease: From pre-manifest to late stage disease. Neuropsychologia. 17: 70: 80-89.
Download Publication - Drouin-Ouellet J, Sawiak SJ, Cisbani G, Lagace M, Kuan WL, Saint-Pierre M, Dury RJ, Alata W, St-Amour I, Mason SL, Calon F, Lacroix S, Gowland PA, Francis ST, Barker RA, Cicchetti F. (2015). Cerebrovascular and blood-brain barrier impairments in Huntington’s disease: Potential implications for its pathophysiology. Ann Neurol. [Epub ahead of print].
Download Publication - Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe J. (2015). Improving repsoinse inhibition in Parkinson’s disease with atomoxetine. Biol Psychiatry. Apr 15; 77(8): 740-8.
Download Publication - Thomas MG, Welch C, Stone L, Allan P, Barker RA, White RB. (2015) PAX6 expression may be protective against dopaminergic cell loss in Parkinson’s disease. CNS Neurol Disord Drug Targets. Aug 20. [Epub ahead of print]
- Mason SL, Barker RA. (2015) Rating Apathy in Huntington’s disease: Patients and Companion’s agree. J Huntington’s Dis. 4(1): 49-59.
Download Publication - Gallo V1, Brayne C, Forsgren L, Barker RA, Petersson J, Hansson O, Lindqvist D, Ruffmann C, Ishihara L, Luben R, Arriola L, Bergareche A, Gavrila D, Erro ME, Vanacore N, Sacerdote C, Bueno-de-Mesquita B, Vermeulen R, Seelen M, Sieri S, Masala G, Ramat S, Kyrozis A, Thricopolou A, Panico S, Mattiello A, Kaaks R, Teucher B, Katzke V, Kloss M, Curry L, Calboli F, Riboli E, Vineis P, Middleton L. (2015) Parkinson’s disease case ascertainment in the EPIC Cohort: The NeuroEPIC4PD Study. Neurodegener Dis. Sep 17. [Epub ahead of print]
- Tedroff J, Waters S, Barker RA, Roos R, Squitieri F. (2015) Antidopaminergic medication is associated with more rapidly progressive Huntington’s disease. J Huntington’s Dis. Jul 1;4 (2): 131-40.
Download Publication - 5. Collins LM, Begeti F, Panin F, Lazar AS, Cruickshank T, Zinman M, Mason SL, Barker RA. (2015) Novel Nut and Bolt task quantifies motor deficits in premanifest and manifest Huntington’s disease. PLoS Curr. Spe 8;7.
- Aresnault D, Drouin-Ouellet J, Saint-Pierre M, Petrou P, Dubois M, Kriz J, Barker RA, Cicchetti A, Cicchetti F. (2015). A novel combinational approach of microstimulation and bioluminescence imaging to study the mechanisms of action of cerebral electrical stimulation in mice. J Physiol. May 15; 593 (10): 2257-78.
Download Publication - Mason SL, Barker RA. (2015). Progress in Huntington’s disease: the search for markers of disease onset and progression. J Neurol. Mar 21.
Download Publication - Vuono R, Winder-Rhodes S, de Silva R, Cisbani G, Drouin-Ouellet J, REGISTRY Investigators of the European Huntington’s Disease Network, Spillantini MG, Cicchetti F, Barker RA. (2015). The role of tau in the pathological process and clinical expression of Huntington’s disease. Brain. Jul;138: 1907-18.
Download Publication - Cox TM, Rosenbloom BE, Barker RA. (2015). Gaucher disease and comorbidities: B-cell malignancy and parkinsonism. Am J Hematol. Jul;90 Suppl 1:S25-8.
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2014
- Goldman JG,diseases. Mov Disord 2014;29(5):608-621.
Download Publication - Barker RA,Journal of Parkinson’s disease 2014;4(4):651-656.
Download Publication - Duncan GW, Khoo TK, Yarnall AJ, O’Brien JT, Coleman SY, Brooks DJ, Barker RA, Burn DJ (2014). Health-related quality of life in early Parkinson’s disease: The impact of nonmotor symptoms. Mov Disord. 29: 195-202.
Download Publication - Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ, Nombela C, Winder-Rhodes S, Evans JR, Rowe JB, Mollenhauer B, Kruse N, Hudson G, Chinnery PF, O’Brien JT, Robbins TW, Wesnes K, Brooks DJ, Barker RA, Burn DJ; On behalf of the ICICLE-PD Study Group (2014). Characterizing mild cognitive impairment in incident Parkinson disease: The ICICLE-PD Study. Neurology. 82:308-16.
Download Publication - Duncan GW, Khoo TK, Coleman SY, Brayne C, Yarnall AJ, O’Brien JT, Barker RA, Burn DJ (2014). The incidence of Parkinson’s disease in the North-East of England. Age Ageing. 43:257-63.
Download Publication - Stott SR, Barker RA (2014). Time course of dopamine neuron loss and glial response in the 6-OHDA striatal mouse model of Parkinson’s disease. Eur J Neurosci. 39:1042-56.
Download Publication - Palfi S, Gurruchaga JM, Ralph GS, Lepetit H, Lavisse S, Buttery PC, Watts C, Miskin J, Kelleher M, Deeley S, Iwamuro H, Lefaucheur JP, Thiriez C, Fenelon G, Lucas C, Brugières P, Gabriel I, Abhay K, Drouot X, Tani N, Kas A, Ghaleh B, Le Corvoisier P, Dolphin P, Breen DP, Mason S, Guzman NV, Mazarakis ND, Radcliffe PA, Harrop R, Kingsman SM, Rascol O, Naylor S, Barker RA, Hantraye P, Remy P, Cesaro P, Mitrophanous KA (2014). Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson’s disease: a dose escalation, open-label, phase 1/2 trial. Lancet. 383:1138-46.
Download Publication - Choi ML, Begeti F, Oh JH, Lee SY, O’Keeffe GC, Clelland CD, Tyers P, Cho ZH, Kim YB, Barker RA (2014) Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington’s disease. Neurobiol Dis. 66:19-27.
Download Publication - Collins LM, Lazic SE, Barker RA (2014) A retrospective analysis of hand tapping as a longitudinal marker of disease progression in Huntington’s disease. BMC Neurol. 14:35.
Download Publication - Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2014) Selective serotonin reuptake inhibition modulates response inhibition in Parkinson’s disease. Brain 137:1145-55.
Download Publication - Huefner A, Septiadi D, Wilts BD, Patel II, Kuan WL, Fragniere A, Barker RA, Mahajan S (2014). Gold nanoparticles explore cells: Cellular uptake and their use as intracellular probes. Methods. 68:354-63.
Download Publication - Herva ME, Zibaee S, Fraser G, Barker RA, Goedert M, Spillantini MG (2014). Anti-amyloid compounds inhibit α-synuclein aggregation induced by protein misfolding cyclic amplification (PMCA). J Biol Chem. 289:11897-905.
Download Publication - Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2014) Improving Response Inhibition in Parkinson’s Disease with Atomoxetine. Biol Psychiatry. 137:1145-55
Download Publication - Kehagia AA, Barker RA, Robbins TW (2014). Revisiting the effects of Parkinson’s disease and frontal lobe lesions on task switching: The role of rule reconfiguration. J Neuropsychol. 8:53-74.
- Breen DP, Vuono R, Nawarathna U, Fisher K, Shneerson JM, Reddy AB, Barker RA (2014). Sleep and circadian rhythm regulation in early Parkinson disease. JAMA Neurol. 71:589-95.
Download Publication - Cicchetti F, Lacroix S, Cisbani G, Vallières N, Saint-Pierre M, St-Amour I, Tolouei R, Skepper JN, Hauser RA, Mantovani D, Barker RA, Freeman TB (2014) Mutant
huntingtin is present in neuronal grafts in huntington disease patients. Ann Neurol. 76:31-42.
Download Publication - Ali FR, Cheng K, Kirwan P, Metcalfe S, Livesey FJ, Barker RA, Philpott A (2014). The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development. 141:2216-24.
Download Publication - Kehagia AA, Housden CR, Regenthal R, Barker RA, Müller U, Rowe J, Sahakian BJ, Robbins TW (2014) Targeting impulsivity in Parkinson’s disease using atomoxetine. Brain 137:1986-97.
Download Publication - Lawson RA, Yarnall AJ, Duncan GW, Khoo TK, Breen DP, Barker RA, Collerton D, Taylor JP, Burn DJ (2014) Quality of Life and Mild Cognitive Impairment in Early Parkinson’s Disease: Does Subtype Matter? J Parkinsons Dis. [Epub ahead of print].
Download Publication - Nombela C, Rowe JB, Winder-Rhodes SE, Hampshire A, Owen AM, Breen DP, Duncan GW, Khoo TK, Yarnall AJ, Firbank MJ, Chinnery PF, Robbins TW, O’Brien JT, Brooks DJ, Burn DJ; the ICICLE-PD study group, Barker RA (2014). Genetic impact on cognition and brain function in newly diagnosed Parkinson’s disease: ICICLE-PD study. Brain. 137: 2743-58.
Download Publication - Zhao JW, Dyson SC, Kriegel C, Tyers P, He X, Fahmy TM, Metcalfe SM, Barker RA. (2014) Modelling of a nanotherapeutic “stroma” to deliver LIF, or XAV939, for promotion of human fetal dopaminergic cells in treatment of Parkinson’s disease. Dis Model Mech. 7:1193-203.
Download Publication - Onorati M, Castigilioni V, Biasci D, Cesana E, Menon R, Vuono R, Talpo F, Goya RL, Lyons PA, Bulfamante GP, Muzio L, Martino G, Toselli M, Farina C, Barker RA, Biella G, Cattaneo E. (2014) Molecular and functional definition of the developing human striatum. Nat Neuroscience. 17:1804-15.
Download Publication - Moore SF, Guzman NV, Mason SL, Williams-Gray CH, Barker RA. (2014). Which patients with Parkinson’s Disease participate in clinical trials? One centre’s experience with a new cell based therapy trial (TRANSEURO). J Parkinsons Dis. 4:671-6.
Download Publication - Lawson RA, Yarnell AJ, Duncan GW, Khoo TK, Breen DP, Barker RA, Collerton D, Taylor JP, Burn DJ. (2014). Severity of mild cognitive impairment in early Parkinson’s disease contributes to poorer quality of life. Parkinsonism Relat Disord. 20: 1071-5.
Download Publication - Kuan WL, Kasis A, Yuan Y, Mason SL, Lazar AS, Barker RA, Goncalves J. (2014). Modelling the natural history of Huntington’s disease progression. J Neurol Neurosurg Psychiatry. 0: 1-7.
Download Publication - Drouin-Ouellett J, St-Amour I, Saint-Pierrer M, Lamontagne-Proulx J, Kriz J, Barker RA, Cicchetti F. (2014). Toll-like receptor expression in the blood and brain of patients and a mouse model of Parkinson’s disease. Int J Neuropsychopharmacol. 7: 18
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2013 - Fallon SJ, Williams-Gray CH, Barker RA, Owen AM, Hampshire A (2013). Prefrontal dopamine levels determine the balance between cognitive stability and flexibility. Cerebral Cortex. 23:361-9.
Download Publication - Hughes LE, Altena E, Barker RA, Rowe JB (2013) Perseveration and Choice in Parkinson’s Disease: The Impact of Progressive Frontostriatal Dysfunction on Action Decisions. Cereb Cortex. 23:1572-81.
Download Publication - Winder-Rhodes* SE, Evans JR, Ban M, Mason SL, Williams-Gray CH, Foltynie T, Duran R, Mencacci NE, Sawcer SJ, Barker RA (2013). Glucocerebrosidase mutations influence the natural history of Parkinson’s disease in a community-based incident cohort. Brain 136:392-399.
Download Publication - Thompson JA, Cruikshank TM, Penailillo LE, Lee JW, Newton RU, Barker RA, Ziman MR (2013). The effects of multidisciplinary rehabilitation in patients with early to middle stage Huntington’s Disease: A pilot study. Eur J Neurol. 20:1325-9.
Download Publication - Carri AD, Onorati M, Lelos MJ, Castiglioni V, Faedo A, Menon R, Camnasio S, Vuono R, Spaiardii P, Talpo F, Toselli M, Martino G, Barker RA, Dunnett SB, Biella G, Cattaneo E (2013). Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation towards authentic DDARP-32 medium sized spiny neurons. Development 140:301-12.
Download Publication - Cisbani G, Freeman TB, Soulet D, Saint-Pierre M, Gagnon D, Parent M, Hauser RA, Barker RA, Cicchetti F (2013). Striatal allografts in Huntington’s Disease patients; impact of diminished astrocytes and vascularisation on graft viability. Brain 136:433-43.
Download Publication - Breen DP, Williams-Gray CH, Mason SL, Foltynie T, Barker RA (2013) Excessive daytime sleepiness and its risk factors in incident Parkinson’ Disease. J Neurol Neurosurg Psychiatry 84:233-4.
Download Publication - Khoo TK, Yarnall AJ, Duncan GW, Coleman S, O’Brien JT, Brooks DJ, Barker RA, Burn DJ (2013). The spectrum of nonmotor symptoms in early Parkinson’s Disease. Neurology 80:276-81.
Download Publication - Barker RA, Mason SL, Harrower TP, Swain RA, Ho AK, Sahakian BJ, Mathur R, Elneil S, Thornton S, Hurrelbrink C, Armstrong RJ, Tyers P, Smith E, Carpenter A, Piccini P, Tai YF, Brooks DJ, Pavese N, Watts C, Pickard JD, Rosser AE, Dunnett SB; the NEST-UK collaboration (2013). The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington’s disease. J Neurol Neurosurg Psychiatry 84:657-65.
Download Publication - Rittman T, Ghosh BC, McColgan P, Breen DP, Evans J, Williams-Gray CH, Barker RA, Rowe JB (2013). The Addenbrooke’s Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders. J Neurol Neurosurg Psychiatry 84:544-51.
Download Publication - Nombela C, Rae CL, Grahn JA, Barker RA, Owen AM, Rowe JB (2013). How often does musIc and rhythm improve patients’ perception of motor symptoms in Parkinson’s Disease ? J. Neurol. 260:1404-5.
Download Publication - Breen DP, Evans JR, Farrell K, Brayne C, Barker RA (2013) Determinants of delayed diagnosis in Parkinson’s disease. J Neurol. 260:1978-81.
Download Publication - Ellul MA, Cross J, Barker RA (2013) L-dopa responsive parkinsonism secondary to a subdural haematoma. J Clin Neurosci. 20:1022-4.
Download Publication - Huefner A, Kuan WL, Barker RA, Mahajan S (2013). Intracellular SERS Nanoprobes For Distinction Of Different Neuronal Cell Types. Nano Lett. 13:2463-70.
Download Publication - Hudson G, Nalls M, Evans JR, Breen DP, Winder-Rhodes S, Morrison KE, Morris HR, Williams-Gray CH, Barker RA, Singleton AB, Hardy J, Wood NE, Burn DJ, Chinnery PF (2013). Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease. Neurology 80:2042-2048.
Download Publication - Williams-Gray CH, Mason SL, Evans JR, Foltynie T, Brayne C, Robbins TW, Barker RA (2013) The CamPaIGN study of Parkinson’s disease: 10-year outlook in an incident population-based cohort. J Neurol Neurosurg Psychiatry. 84:1258-64.
Download Publication - Fallon SJ, Hampshire A, Williams-Gray CH, Barker RA, Owen AM (2013). Putative cortical dopamine levels affect cortical recruitment during planning. Neuropsychologia. 51:2194-201.
Download Publication - Begeti F, Tan AY, Cummins GA, Collins LM, Guzman NV, Mason SL, Barker RA (2013) The Addenbrooke’s Cognitive Examination-Revised accurately detects cognitive decline in Huntington’s disease. J Neurol. 260:2777-85.
Download Publication - Whitworth SR, Loftus AM, Skinner TC, Gasson N, Barker RA, Bucks RS, Thomas MG (2013). Personality affects aspects of health-related quality of life in Parkinson’s disease via psychological coping strategies..J Parkinsons Dis. 3:45-53.
Download Publication - Brundin P, Barker RA, Conn PJ, Dawson TM, Kieburtz K, Lees AJ, Schwarzschild MA, Tanner CM, Isaacs T, Duffen J, Matthews H, Wyse RK (2013). Linked clinical trials–the development of new clinical learning studies in Parkinson’s disease using screening of multiple prospective new treatments. J Parkinsons Dis. 3:231-9.
Download Publication - Antoniades CA, Xu Z, Carpenter RH, Barker RA (2013) The Relationship between Abnormalities of Saccadic and Manual Response Times in Parkinson’s Disease. J Parkinsons Dis. 3:557-63.
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2012 - Litvan I, Goldman JG, Troster AI, Schmand BA, Weintraub D, Petersen RC, Mollenhauer B, Adler CA, Marder K, Williams-Gray CH, Aarsland D, Kulisevsky J, Rodriguez-Oroz MC, Burn DJ, Barker RA, Emre M (2012) Diagnostic criteria for Mild Cognitive Impairment in Parkinson’s disease: Movement Disorder Society task Force guidelines. Mov.Disorders. 27:349-56.
Download Publication - Charlesworth G, Gandhi S, Bras JM, Barker RA, Burn DJ, Chinnery PF, Gentleman SM, Guerreiro R, Hardy J, Holton JL, Lees A, Morrison K, Sheerin UM, Williams N, Morris H, Revesz T, Wood NW (2012). Tau acts as an independent genetic risk factor in pathologically proven PD. Neurobiol Aging. 33:838.e7-11.
Download Publication - Antoniades CA, Buttery P, FitzGerald JJ, Barker RA, Carpenter RH, Watts C (2012). Deep brain stimulation: eye movements reveal anomalous effects of electrode placement and stimulation. PLoS One. 7:e32830.
Download Publication - Robertson L, Santini H, O’Donovan KL, Squitieri F, Barker RA, Rakowicz M, Landwehrmeyer GB, Quarrell O (2012). Current Pharmacological Management in Juvenile Huntington’s Disease. Version 3. PLoS Curr. Feb 15 [revised 2012 Mar 26];4:RRN1304.
- Höglinger GU, Barker RA, Hagg T, Arias-Carrión O, Caldwell MA, Hirsch EC (2012). Quantitative evaluation of the human subventricular zone. Brain. 135:e221.
Download Publication - Rae CL, Correia MM, Altena E, Hughes LE, Barker RA, Rowe JB (2012). White matter pathology in Parkinson’s disease: The effect of imaging protocol differences and relevance to executive function. Neuroimage. 62:1675-84.
Download Publication - Wu K, O’Keefe, Politis M, O’Keeffe GC, Robbins TW, Bose SK, Brooks DJ, Piccini P, Barker RA (2012). The catechol-O-methyltransferase Val 158Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson’s Disease; a PET study. Brain. 135:2449-57.
Download Publication - Kuan W-L, Poole E, Fletcher M, Karniely S, Tyers P, Wills M, Barker RA*, Sinclair JH* (2012) A novel neuroprotective therapy for Parkinson’s disease using a viral non-coding RNA that protects mitochondrial Complex I activity. J Exp Med. 2091-10 (*equal last author).
Download Publication - McColgan P, Evans JR, Breen DP, Mason SL, Barker RA, Williams-Gray CH (2012). Addenbrooke’s Cognitive Examination –Revised for mild cognitive impairment in Parkinson’s Disease. Mov.Disorders. 27:1173-7.
- Winder-Rhodes S, Garcia-Reitbock P, Ban M, Evans JR, Jacques TS, Kemp[inen A, Foltynie T, Williams-Gray CH, Chinnery PF, Hudson G, Burn DJ, Allcock LM, Sawcer SJ, Barker RA*, Spillantini MG* (2012) Genetics and pathological links between Parkinson’s Disease and the lysosomal disorder Sanfilippo Syndrome. Mov Disord. 27:312-5.[* Equal senior authors].
Download Publication - Ribeiro D, Laguna Goya R, Ravindran G, Vuono R, Parish CL, Foldi C, Piroth T, Yang S, Parmar M, Nikkhah G, Hjerling-Leffler J, Lindvall O, Barker RA, Arenas E (2012). Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens. Neurobiol Dis. 49C:118-127.
Download Publication - Kilarski LL, Pearson JP, Newsway V, Majounie E, Knipe MD, Misbahuddin A, Chinnery PF, Burn DJ, Clarke CE, Marion MH, Lewthwaite AJ, Nicholl DJ, Wood NW, Morrison KE, Williams-Gray CH, Evans JR, Sawcer SJ, Barker RA, Wickremaratchi MM, Ben-Shlomo Y, Williams NM, Morris HR (2012). Systematic Review and UK-Based Study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson’s disease. Mov Disord. 27:1522-9.
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2011 - Goodman AO, Rogers L, Pilsworth S, McAllister CJ, Shneerson JM, Morton AJ, Barker RA (2011) . Asymptomatic Sleep Abnormalities Are a Common Early Feature in Patients with Huntington’s Disease.Curr Neurol Neurosci Rep. 11:211-7.
Download Publication - Cordero-Llana O, Scott SA, Maslen SL, Anderson JM, Boyle J, Chowhdury RR, Tyers P, Barker RA, Kelly CM, Rosser AE, Stephens E, Chandran S, Caldwell MA (2011) Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells. Cell Death Differ. 18:907-13.
Download Publication - Decressac M, Wright B, David B, Tyers P, Jaber M, Barker RA, Gaillard A. (2011) Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis. Hippocampus. 21:233-8.
Download Publication - De Wit S, Barker RA, Dickinson A, Cools R (2011) Habitual versus goal directed action control in Parkinson’s Disease. J Cogn Neurosci. 23:1218-29.
Download Publication - Bucks RS, Cruise KE, Skinner TC, Loftus AM, Barker RA, Thomas MG (2011) Coping processes and health-related quality of life in Parkinson’s disease. Int J Geriatr Psychiatry. 26:247-55.
Download Publication - Politis M, Pavese N, Tai YF, Kiferle L, Mason SL, Brooks DJ, Tabrizi SJ, Barker RA, Piccini P (2011) Microglial activation in regions related to cognitive function predicts disease onset in Huntington’s disease: A multimodal imaging study. Hum Brain Mapp. 32:258-70.
Download Publication - Pernecsky R, Ghosh BCP, Hughes L, Carpenter RHS, Barker RA, Rowe JB (2011) Saccadic latency in Parkinson’s disease correlates with executive function and brain atrophy, but not motor severity. Neurobiol.Dis. 43:79-85.
Download Publication - International Parkinsons Disease Genomics Consortium (2011) Imputation of sequence variants for identification of genetic risks for Parkinson’s disease: a meta-analysis of genome wide association studies. Lancet 277:641-649.
- Goodman AO, Barker RA (2011) Body composition in premanifest Huntington’s disease reveals lower bone density compared to controls. PLoS Curr. Feb 28:3:RRN1214.
- Evans JR, Mason SL, Williams-Gray CH, Foltynie T, Trotter M, Barker RA (2011) the factor structure of the UPDRS as an index of disease progression in Parkinson’s disease. J.Park.Dis. 21:1-8.
Download Publication - The UK Parkinson’s Disease Consortium and The Wellcome Trust Case Control Consortium 2 (2011) Dissection of the genetics of Parkinson’s disease identifies an additional association 5′ of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet. 20:345-53.
Download Publication - Laguna Goya R, Busch R, Mathur R, Coles AJ, Barker RA (2011) Human fetal neural precursor cells can up-regulate MHC class I and class II expression and elicit CD4 and CD8 T cell proliferation. Neurobiol Dis. 41:407-14.
Download Publication - Nopoulos PC, Aylward EH, Ross CA, Mills JA, Langbehn DR, Johnson HJ, Magnotta VA, Pierson RK, Beglinger LJ, Nance MA, Barker RA, Paulsen JS; the PREDICT-HD Investigators and Coordinators of the Huntington Study Group (2011) Smaller intracranial volume in prodromal Huntington’s disease: evidence for abnormal neurodevelopment.. Brain. 134:137-42.
Download Publication - Evans JR, Mason SL, Williams-Gray CH, Foltynie T, Brayne C, Robbins TW, Barker RA (2011) The natural history of treated Parkinson’s Disease in an incident, community based cohort. J Neurol Neurosurg Psychiatry. 82:1112-8.
Download Publication - International Parkinson’s Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2) 2011. A two-stage meta-analysis identifies several new loci for Parkinson’s disease.PLoS Genet. 7:e1002142.
Download Publication - O’Keefe G, Barker RA (2011) Dopamine stimulates EGF release from adult neural precursor cells derived from the subventricular zone via ADAMs. Neuroreport. 22:956-8.
- De Yebenes JG, Landwehrmeyer B, Squitieri F, Reilamn R, Rosser A, Barker RA, Saft C, Magnet MK, Sword A, Rembratt A, Tedroff J for the MermaiHD study investigators (2011) Pridopidine for the treatment of motor function in patients with Huntington’s disease (MermaiHD): a phase 3, randomised, placebo-controlled trial. Lancet Neurol. 10:1049-57.
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2010 - Rowe JB, Hughes LE, Barker RA, Owen AM (2010) Dynamic causal modelling of effective connectivity from fMRI: are results reproducible and sensitive to Parkinson’s disease and its treatment? Neuroimage. 2010 Sep;52(3):1015-26. Epub 2010 Jan 4.
Download Publication - Goya RL, Tyers P, Barker RA (2010). Adult neurogenesis is unaffected by afunctional knock out of MHC class I in mice. Neuroreport. 21:349-53.
- Hobbs NZ, Barnes J, Frost C, Henley SMD, Wild EJ, MacDonald K, Barker RA, Scahill RI, Fox NC, Tabrizi SJ (2010). Onset and progression of pathologic atrophy in Huntington Disease: A longitudinal MRi imaging study. AJNR Am J Neuroradiol. 31:1036-41.
Download Publication - Cools R, Rogers R, Barker RA, Robbins TW (2010) Top-Down Attentional Control in Parkinson’s Disease: Salient Considerations. J Cogn Neurosci. 22:848-59
Download Publication - Hughes LE, Barker RA, Owen AM, Rowe JB (2010). Parkinson’s disease and healthy aging: Independent and interacting effects on action selection. Hum Brain Mapp. 31:1886-99.
Download Publication - Rowe JB, Hughes L, Williams-Gray CH, Bishop S, Fallon S, Barker RA, Owen AM (2010) .The val(158)met COMT polymorphism’s effect on atrophy in healthy aging and Parkinson’s disease. Neurobiol Aging. 31:1064-8.
Download Publication - Wild EJ, Henley SM, Hobbs NZ, Frost C, MacManus DG, Barker RA, Fox NC, Tabrizi SJ (2010) Rate and acceleration of whole-brain atrophy in premanifest and early Huntington’s disease. Mov Disord. 25:888-95.
Download Publication - Saiki M, Baker A, Williams-Gray CH, Foltynie T, Goodman RS, Taylor CJ, Compston DAS, Barker RA, Sawcer SJ, Goris A (2010). Association of the human leucocyte antigen region with susceptibility to Parkinson’s disease. J Neurol Neurosurg Psychiatry. 81:890-1.
Download Publication - Calder AJ, Keane J, Young AW, Lawrence AD, Mason S, Barker RA (2010) The relation between anger and different forms of disgust: Implications for emotion recognition impairments in Huntington’s Disease. Neuropsychologia. 48:2719-29.
Download Publication - Antoniades CA, Xu Z, Mason SL, Carpenter RH, Barker RA (2010) Huntington’s disease: changes in saccades and hand-tapping over 3 years.. J .Neurol. 257:1890-8.
Download Publication - Taylor PL, Barker RA, Blume KG, Cattaneo E, Colman A, Deng H, Edgar H, Fox IJ, Gerstle C, Goldstein LS, High KA, Lyall A, Parkman R, Pitossi FJ, Prentice ED, Rooke HM, Sipp DA, Srivastava A, Stayn S, Steinberg GK, Wagers AJ, Weissman IL. (2010) Patients Beware: Commercialized Stem Cell Treatments on the Web. Cell Stem Cell. 7:43-49.
Download Publication - Decressac M, Wright B, Tyers P, Gaillard A, Barker RA (2010) Neuropeptide Y modifies the disease course in the R6/2 transgenic model of Huntington’s Disease. Exp Neurol. 226:24-32.
Download Publication - Aarsland D, Bronnick K, Williams-Gray C, Weintraub D, Marder K, Kulisevsky J, Burn D, Barone P, Pagonabarraga J, Allcock L, Santangelo G, Foltynie T, Janvin C, Larsen
JP, Barker RA, Emre M (2010) Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis. Neurology 75:1062-9.
Download Publication - Mason SL, Wijeyekoon R, Swain R, Ho A, Smith EL, Sahakian B, Barker RA (2010). Cognitive follow up of a small cohort of Huntington’s disease patients over a 5 year period. PLoS Curr. 2;2. pii: RRN1174.
- Paulsen JS, Wang C, Duff K, Barker R, Nance M, Beglinger L, Moser D, Williams JK, Simpson S, Langbehn D, van Kammen DP; PREDICT-HD Investigators of the Huntington Study Group (2010). Challenges assessing clinical endpoints in early Huntington disease. Mov Disord. 25:2595-603.
Download Publication - Goodman AO, Morton AJ, Barker RA (2010) Identifying sleep disturbances in Huntington’s disease using a simple disease-focused questionnaire. PLoS Curr. 2010 Oct 15;2:RRN1189.
2009 - Kehagia AA, Cools R, Barker RA, Robbins TW (2009) Switching between abstract rules reflects disease severity but not dopaminergic status in Parkinson’s disease. Neuropsychologia 47:1117-27.
Download Publication - Thomas M, Tyers P, Lazic SE, Barker RA, Beazley L, Ziman M (2009) Graft outcomes influenced by co-expression of Pax7 in graft and host tissue. J.Anat. 214:396-405.
Download Publication - Henley SMD, Wild EJ, Hobbs NZ, Frost C, MacManus DG, Barker RA, Fox NC, Tabrizi SJ (2009) Whole-brain atrophy as a measure of progression in premanifest and early huntington’s disease. Mov.Disorders 24:932-6.
- Henley SMD, Wild EJ, Hobbs NZ, Scahill RI, Ridgway GR, MacManus DG, Barker RA, Fox NC, Tabrizi SJ (2009) Relationship between CAG repeat length and brain volume in premanifest and early Huntington’s disease. J.Neurol. 256:203-212.
- Lewis SJ, Barker RA (2009) Understanding the dopaminergic deficits in Parkinson’s disease: Insights into disease heterogeneity. J Clin Neurosci. 16:620-5.
Download Publication - O’Keefe G, Tyers P, Aarsland D, Dalley J, Caldwell MA*, Barker RA* (2009)Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc.Natl.Acad Sci. 106:8754-9 [*joint senior authors].
Download Publication - Williams-Gray CH, Goris A, Saiki M, Foltynie T, Compston DA, Sawcer SJ, Barker RA (2009). Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson’s Disease. J Neurol. 256:493-8.
Download Publication - Lazic SE, Mason SL, Michell AW, Barker RA (2009) Visualising disease progression on multiple variables using vector plots and data plots. BMC Med Res Methodol. 9:32.
Download Publication - Hobbs N, Wild EJ, Leung KK, Frost C, Barker RA, Scahill RI, Barnes J, Fox NC, Tabrizi SJ (2009). Automated quantification of caudate atrophy by local registration of serial MRI: evaluation and application in Huntington’s disease. NeuroImage 47:1659-65.
Download Publication - W.Phillips, AW Michell, H Pruess, RA Barker (2009). Animal Models of neurodegenerative diseases. Methods Mol Biol. 549:137-55.
- Clelland CD, Choi M, Romberg C, Clemenson GD Jr, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA*, Gage FH*, Bussey TJ (2009). A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325;210-213. [*joint senior authors].
Download Publication - O’Keefe G, Caldwell MA*, Barker RA* (2009) Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain. Cell Cycle 8:2888-94.
- Williams-Gray CH, Evans JR, Goris A, Foltynie T, Ban M, Robbins TW, Brayne C, Kolachana BS, Weinberger DR, Sawcer SJ, Barker RA (2009). The distinct cognitive syndromes of Parkinson’s disease: 5 year follow-up of the CamPaIGN cohort. Brain. 132:2958-69.
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